Our mass spectrometry (MS) instrumentation includes a state of the art Xevo G2S high mass resolution (30K) and high mass accuracy (3-5ppm) quadrupole time of flight (QTof) MS detector.
The detector is complemented with an impressive front end that includes an Aquity I-class Ultra-high Performance Liquid Chromatography (UPLC) system, PhotoDiode Array (PDA) UV detector, and Electrospray Ionization (ESI) and Atmospheric Pressure Chemical Ionization (APCI) source options. This advanced system allows for seamless qual/quant analytical workflows, with multiple channels of instrument and detector setup, allowing continuous lock-mass correction for optimal mass accuracy. In-depth structural characterization studies are facilitated by parallel full scan, MS/MS, or MSE (E for everything) fragmentation modes. Importantly, UV and MS data output are synchronized yielding correlated data captured in a single output, allowing for one stop data analysis and data mining.
The Mass Spec Lab analytical portfolio has grown and now includes a Xevo G2S compatible Atmospheric Pressure Gas Chromatograph (APGC) interface with an Agilent 7890B GC system. The APGC source couples the GC outlet stream to the Xevo G2S system which provides “soft” atmospheric pressure ionization of chemical analytes, and detection of intact molecular ions which might not be detected in traditional GC-MS EI or CI systems. The combination of APGC “soft” ionization, high mass accuracy QTof detection, and advanced data processing and peak mining via Progenesis QI software offers a rare analytical capability amongst analytical services providers.
The GC workhorse Agilent 7890A and 5975C with high sensitivity triple axis HED-EM (High Energy Dynode-Electron Multiplier) MS detector with electron ionization (EI) and NIST database search adds an orthogonal analytical approach.
Automated sample injection and advanced data acquisition and Mass Spec Lab data processing software complete a robust analytical workflow for comprehensive (polar, non-polar, volatile, semivolatile, nonvolatile) chemical characterization spanning the spectrum from routine quality control to challenging research samples in complex matrices.
While we consider the quality of our mass spectrometers vital to our business, we have also paid close attention to building a well outfitted laboratory to complete the package. We utilize an array of instruments and supplies which enable flexibility and creative innovation. Our lab includes an ATR-FTIR spectrometer, a Differential Scanning Calorimeter (DSC), a Gel Permeation Chromatography (GPC) system, multiple LC and GC systems set up with different detectors including fluoresence, refractive index and FID, a UV-VIS spectrophotometer and a high end Leica Stereomicroscope.